Yixiang WANG


Prof. James F GRIFFITH
Yixiang WANG

MMed (Radiology). PhD




  • Magnetic Resonance Imaging; Spine degeneration; Osteoporotic fracture

Research Interest

  • Epidemiology & Imaging of Osteoporosis, bone mineral density, Osteoporotic fracture
  • Magnetic Resonance Research: diffusion imaging, MR Relaxometry

Education Profile

  • Post-doctoral Fellow, The University of Sheffield, 1996
  • PhD in Medical Science, Shanghai Medical University,1995
  • Doctoral Diploma in Radiology, Shanghai Medical University, 1994
  • Master degree of Medicine, Zhejiang Medical University, 1991


  • PhD and MPhil post-graduate student supervisor


Internal Service

  • Head, Graduate Students Division. 2015-present
  • Supervisor, research unit
  • SSM student examiner
  • PhD thesis examiner

External Service

  • Editor-in-Chief. Quantitative Imaging in Medicine and Surgery
  • Adjunct Professor, Jinan University, Guangzhou, China

Active Member

  • European Society of Musculoskeletal Radiology osteoporosis & metabolism subcommittee
  • Academic Advisor, for the Faculty of Health Sciences, the National University of Malaysia, Malaysia,
  • External graduate thesis external examiner 


In recent years, Dr Wang’s research has focused on three directions: (1) new techniques of liver MRI and diffusion MRI; (2) spine degenerative diseases; (3) bone mineral density and osteoporotic fracture. He pioneered a number of liver MRI techniques such as diffusion derived vessel density (DDVD), T1rho, CEST, 3-dimenional analysis of IVIM parameters. His work on epidemiology of spine degeneration including disc space narrowing, spondylolisthesis, and osteoporotic fracture provides reference standard for East Asians, and also deepened the understanding of pathophysiology of spine degeneration. To reconcile with the lower lifetime risk of fragility fracture among East Asian populations (than those among Caucasians), he proposed new criteria for classifying densitometric osteoporosis for East Asians. He published the first radiographic osteoporotic vertebral fracture diagnosis expert consensus as the leading author, which majorly revised the earlier diagnosis criteria. Currently, he is actively exploring the clinical use of  a new imaging biomarker DDVD devised by him, with very promising results in the fields of placenta medicine and oncology. He is the principal developer of an AI-enabled automated vertebral fracture detection software (Ofeye series). He also proposed a new disease entity endplatitis short vertebrae, and a new classification for Schmorl’s node with congenital Schmorl’s node as a pseudo-Schmorl’s node.

He has published >360 papers, and his works have been cited > 14, 800 times, with H-index > 59 according to Web-of-Science (google scholar: citation > 22, 000 times, H-index > 69 ).



  1. Wáng YXJ, Diacinti D, Aparisi Gómez MP, Ruiz Santiago F, Becce F, Tagliafico AS, Prakash M,  Isaac A, Dalili D, Griffith JF, Guglielmi G, Bazzocchi A. Radiological diagnosis of prevalent osteoporotic vertebral fracture on radiographs: an interim consensus from a group of experts of the ESSR osteoporosis & metabolism subcommittee. Skeletal Radiol 2024 https://doi.org/10.1007/s00256-024-04678-4
  2. Wang YX. Endplatitis short vertebrae. Quant Imaging Med Surg. 2024;14:2725-2733.

  3. Wáng YXJ, Blake GM, Tang SN, Guermazi A, Griffith JF. Quantitative CT lumbar spine BMD cutpoint value for classifying osteoporosis among older East Asian women should be lower than the value for Caucasians. Skeletal Radiol. 2024. doi: 10.1007/s00256-024-04632-4.
  4. Li XM, Yao DQ, Quan XY, Li M, Chen W, Wáng YXJ. Perfusion of hepatocellular carcinomas measured by diffusion-derived vessel density biomarker: Higher hepatocellular carcinoma perfusion than earlier intravoxel incoherent motion reports. NMR Biomed. 2024:e5125.
  5. Wáng YXJ, Ma FZ. A tri-phasic relationship between T2 relaxation time and magnetic resonance imaging (MRI)-derived apparent diffusion coefficient (ADC). Quant Imaging Med Surg. 2023;13:8873-8880.
  6. Wáng YXJ, Griffith JF, Blake GM, Diacinti D, Xiao BH, Yu W, Su Y, Jiang Y, Guglielmi G, Guermazi A, Kwok TCY. Revision of the 1994 World Health Organization T-score definition of osteoporosis for use in older East Asian women and men to reconcile it with their lifetime risk of fragility fracture. Skeletal Radiol. 2024;53:609-625.
  7. He J, Chen C, Xu L, Xiao B, Chen Z, Wen T, Wáng YXJ, Liu P. Diffusion-Derived Vessel Density Computed From a Simplified Intravoxel Incoherent Motion Imaging Protocol in Pregnancies Complicated by Early Preeclampsia: A Novel Biomarker of Placental Dysfunction. Hypertension. 2023;80:1658-1667.
  8. Yu WL, Xiao BH, Ma FZ, Zheng CJ, Tang SN, Wáng YXJ. Underestimation of the spleen perfusion fraction by intravoxel incoherent motion MRI. NMR Biomed. 2023;36:e4987.
  9. Wang YX, Yuan J, Chu ES, Go MY, Huang H, Ahuja AT, Sung JJ, Yu J. T1rho MR imaging is sensitive to evaluate liver fibrosis: an experimental study in a rat biliary duct ligation model. Radiology. 2011;259:712
  10. Wang YX, King AD, Zhou H, Leung SF, Abrigo J, Chan YL, Hu CW, Yeung DK, Ahuja AT. Evolution of radiation-induced brain injury: MR imaging-based study. Radiology. 2010;254:210-8.
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